Tonsil Stained with Anti-ZAP70
ZAP-70, a Syk-family protein tyrosine kinase, plays a critical role in mediating T cell signal transduction in response to T cell antigen receptor (TCR) activation. It is primarily expressed in T cells and natural killer (NK) cells. Antibody to ZAP-70 also labels mast cells, basophils and pro/pre-B cells but not mature B cells. ZAP-70 antibody is useful in identification of the subtype of chronic lymphocytic leukemia (CLL). Anti-ZAP-70 is positive in CLL with mutation of the immunoglobulin heavychain variable region (IgVH) genes, but negative in CLL without IgVH mutation. ZAP-70 expression is associated with disease progression in CLL
ZAP-70, a Syk-family protein tyrosine kinase, plays a critical role in mediating T cell signal transduction in response to T cell antigen receptor (TCR) activation. It is primarily expressed in T cells and natural killer (NK) cells. Antibody to ZAP-70 also labels mast cells, basophils and pro/pre-B cells but not mature B cells. ZAP-70 antibody is useful in identification of the subtype of chronic lymphocytic leukemia (CLL). Anti-ZAP-70 is positive in CLL with mutation of the immunoglobulin heavychain variable region (IgVH) genes, but negative in CLL without IgVH mutation. ZAP-70 expression is associated with disease progression in CLL
