Cervical Ca stain with anti TOP2A
The TOP2A gene is approximately 30 kb in size and encodes a 170 kDa protein. DNA Topoisomerase II alpha (Topo IIa) is a nucleic enzyme that affects the topological structure of DNA by interacting with the double-helix DNA, thus playing an important role in DNA replication, transcription, recombination, condensation, and segregation. Topo IIa is essential in the separation of daughter strands at the end of DNA replication. Failure to separate these strands leads to cell death. In cancers. The Top2A is highly expressed in highly-proliferating cells. Topoisomerase II Alpha is expressed in proliferating cells and in numerous human malignant tumors, including colon, gastric and breast cancers, Lymphomas and others. Topo II-alpha has been used as a proliferation marker and it can also serve as a molecular target for a variety of anticancer drugs that are used clinically.
The TOP2A gene is approximately 30 kb in size and encodes a 170 kDa protein. DNA Topoisomerase II alpha (Topo IIa) is a nucleic enzyme that affects the topological structure of DNA by interacting with the double-helix DNA, thus playing an important role in DNA replication, transcription, recombination, condensation, and segregation. Topo IIa is essential in the separation of daughter strands at the end of DNA replication. Failure to separate these strands leads to cell death. In cancers. The Top2A is highly expressed in highly-proliferating cells. Topoisomerase II Alpha is expressed in proliferating cells and in numerous human malignant tumors, including colon, gastric and breast cancers, Lymphomas and others. Topo II-alpha has been used as a proliferation marker and it can also serve as a molecular target for a variety of anticancer drugs that are used clinically.
