PAX-8 is 1 of 9 members of paired box gene (PAX) family of transcription factors that regulate organogenesis. PAX8 is involved in development of the central nervous system, eye, kidney, thyroid gland, organs derived from the mesonephric (Wolffian) duct and organs derived from the Müllerian duct. It is expressed in epithelial neoplasms of thyroid, thymic, ovarian, endometrial, endocervical, fallopian tube and renal origin. Pax8 is a useful marker in the differential diagnosis of ovarian and breast carcinomas.
PAX-8 is 1 of 9 members of paired box gene (PAX) family of transcription factors that regulate organogenesis. PAX8 is involved in development of the central nervous system, eye, kidney, thyroid gland, organs derived from the mesonephric (Wolffian) duct and organs derived from the Müllerian duct. It is expressed in epithelial neoplasms of thyroid, thymic, ovarian, endometrial, endocervical, fallopian tube and renal origin. Pax8 is a useful marker in the differential diagnosis of ovarian and breast carcinomas.
