Breast Cancer stained with Anti-Nucleophosmin
Nucleophosmin, also known as Nucleolar phoshoprotein B23, Nucleolar protein NO38, or Numatrin, and encoded by the gene name NPM1 and NPM, is a major nucleolar phospoprotein that is mainly located within the nucleolar granular compartment, where peribosomes are assembled. Nucleophosmin is a multifunctional protein that is over expressed in actively proliferating cells and cancer cells. It is involved in cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF.
Nucleophosmin, also known as Nucleolar phoshoprotein B23, Nucleolar protein NO38, or Numatrin, and encoded by the gene name NPM1 and NPM, is a major nucleolar phospoprotein that is mainly located within the nucleolar granular compartment, where peribosomes are assembled. Nucleophosmin is a multifunctional protein that is over expressed in actively proliferating cells and cancer cells. It is involved in cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF.
