Rhabdomyosarcoma stained with Anti-Myogenin_
Myogenic factors are transcription factors consisting of an amino acid-rich region and a helix-loop-helix(HLH) structure, which can promote muscle devlopment and maintain muscle-specific gene expression by transactivation. Myogenin, one of the myogenic regulatory factors, plays a key role in determining the commitment and differentiation of primitive mesenchymal cells into skeletal muscle. The expression of Myogenin is restricted to cells of skeletal muscle origin, but it is not detected in adult skeletal muscles. It is therefore considered to be an extremely reliable and specific marker for diagnosing rhabdomyosarcomas.
Myogenic factors are transcription factors consisting of an amino acid-rich region and a helix-loop-helix(HLH) structure, which can promote muscle devlopment and maintain muscle-specific gene expression by transactivation. Myogenin, one of the myogenic regulatory factors, plays a key role in determining the commitment and differentiation of primitive mesenchymal cells into skeletal muscle. The expression of Myogenin is restricted to cells of skeletal muscle origin, but it is not detected in adult skeletal muscles. It is therefore considered to be an extremely reliable and specific marker for diagnosing rhabdomyosarcomas.
