Lymph Node stained with Anti-MCM6
Six main highly conserved DNA-binding members(MCM6 to-7) have been well documented to interact with each other,forming a heterohexamer complex. upon activation by cyclin-dependent kinases,MCM proteins bind to chromatin in late mitosis and G1 lead to initiation of DNA systhesis.MCM proteins disassociate from chromatin after DNA replication to restrict chromosome replication to one round per cell cycle. MCM proteins have been suggested as potentially important biomarkers for cancer diagnosis and prognosis.High MCM6 expression was associated with a significantly shorter survival in mantle cell lymphoma.Increased MCM6 labelling was also associated with chondrosarcoma histopathological grade.Further,it was shown to be more eefect in identifying proliferative activity compared to Ki67.Examination of a combination of MCM2 to -7 demonstrated significantly diminished survival when four or more MCM are overexpressed in ER+ breast cancers.
Six main highly conserved DNA-binding members(MCM6 to-7) have been well documented to interact with each other,forming a heterohexamer complex. upon activation by cyclin-dependent kinases,MCM proteins bind to chromatin in late mitosis and G1 lead to initiation of DNA systhesis.MCM proteins disassociate from chromatin after DNA replication to restrict chromosome replication to one round per cell cycle. MCM proteins have been suggested as potentially important biomarkers for cancer diagnosis and prognosis.High MCM6 expression was associated with a significantly shorter survival in mantle cell lymphoma.Increased MCM6 labelling was also associated with chondrosarcoma histopathological grade.Further,it was shown to be more eefect in identifying proliferative activity compared to Ki67.Examination of a combination of MCM2 to -7 demonstrated significantly diminished survival when four or more MCM are overexpressed in ER+ breast cancers.
