Brain Ca stained with Anti HSP70
The heat shock proteins(HSPs) are a conserved family of ubiquitously expressed proteins that functions to protect cells from various environmental damage.Two proteins within the family , HSP70 and HSP27 demonstrate strong anti-apoptotic activity;its over expression allow cells to survive in various conditions . HSPs have been implicated in tumorigenesis-affecting cell cycle regulation,multi drug resistance and modulating p53 function. HSP70 has been studied in a variety of malignancies,Including breast ,Lung ,Oral,prostate and uterine-cervical cancers.A majority of results associated HSP70 overexpression with poor prognosis and resistance to therapy.Recently ,HSP70 diagnostic utility was established in identifying hepatocellular carcinoma (HCC). HSP70 was the most abundantly up-regulated gene in advanced HCC and its immunoreactivity was seen in the majaority of HCC .Its sensitivity and specificity were determined as 74% and 98%,respectively. Furthermore , a three antibody panel with HSP70, Glypican 3 and Glutamine synthetase is capable of distinguishing HCC from high grade dysplactic nodules with 100% specificity when 2 markers are positive.
The heat shock proteins(HSPs) are a conserved family of ubiquitously expressed proteins that functions to protect cells from various environmental damage.Two proteins within the family , HSP70 and HSP27 demonstrate strong anti-apoptotic activity;its over expression allow cells to survive in various conditions . HSPs have been implicated in tumorigenesis-affecting cell cycle regulation,multi drug resistance and modulating p53 function. HSP70 has been studied in a variety of malignancies,Including breast ,Lung ,Oral,prostate and uterine-cervical cancers.A majority of results associated HSP70 overexpression with poor prognosis and resistance to therapy.Recently ,HSP70 diagnostic utility was established in identifying hepatocellular carcinoma (HCC). HSP70 was the most abundantly up-regulated gene in advanced HCC and its immunoreactivity was seen in the majaority of HCC .Its sensitivity and specificity were determined as 74% and 98%,respectively. Furthermore , a three antibody panel with HSP70, Glypican 3 and Glutamine synthetase is capable of distinguishing HCC from high grade dysplactic nodules with 100% specificity when 2 markers are positive.
