Urothelial Ca stained with Anti-GATA3
GATA3 binding Protein 3(GATA3) is a Zinc finger transcription factor that regulates the development in a variety of tissue and cell types. It has been detected in trophoblasts,epidermis,mammary and salivary glands,urothelia,distal nephron and subsets of T-lymphocytes. GATA3 has been widely investigated as a marker for breast and urothelial carcinomas. GATA3 expression was detected in the majority of primary(90%) and metastatic(87%) mammary carcinomas. positivity in triple negative tumors is repeated lower(43-67%). GATA3 is also considered a sensitive marker in the differential diagnosis of urothelial carcinoma from Prostate adenocarcinoma,Labelling the majority of urothelial carcinomas(86%) and none of prostate adenocarcinoma.It also demonstrates superior sensitivity compared to other urothelialmarkers: Thormbomodulin and Uroplankin III. In a Large scale analysis of 2,500 tumors,GATA3 was also detected in various epithelial and mesenchymal tumors. This marker is a sensitive but not completely specific for mammary and urothelial Carcinomas.
GATA3 binding Protein 3(GATA3) is a Zinc finger transcription factor that regulates the development in a variety of tissue and cell types. It has been detected in trophoblasts,epidermis,mammary and salivary glands,urothelia,distal nephron and subsets of T-lymphocytes. GATA3 has been widely investigated as a marker for breast and urothelial carcinomas. GATA3 expression was detected in the majority of primary(90%) and metastatic(87%) mammary carcinomas. positivity in triple negative tumors is repeated lower(43-67%). GATA3 is also considered a sensitive marker in the differential diagnosis of urothelial carcinoma from Prostate adenocarcinoma,Labelling the majority of urothelial carcinomas(86%) and none of prostate adenocarcinoma.It also demonstrates superior sensitivity compared to other urothelialmarkers: Thormbomodulin and Uroplankin III. In a Large scale analysis of 2,500 tumors,GATA3 was also detected in various epithelial and mesenchymal tumors. This marker is a sensitive but not completely specific for mammary and urothelial Carcinomas.
