Tonsil stained with Anti-FOXP3
FOXP3 is a member of the forkhead box(FOX) transcription factors, found to be a regulator in the development and function of regulatory T cells (Treg). While FOXP3 has been widely accepted as the best marker for Treg identification, it can also be transiently expressed on non-regulatory CD4+ T-cells upon T-cell antigen receptor activation, and in nonlymphocytic normal or cancer cells. Tregs are defined as immunosuppressive T cells that can mediate local suppression of antitumor immunity and also inhibit functions of dendritic cells, natural killer cells and B cells. Recruitment of Tregs into tumors has been suggested as one of the mechanisms by which malignant cells evade host immunity. treg tumor infiltration, an enlarged pool of Treg in the peripheral blood, and draining lymph nodes have been observed in multi cancer types. Intratumoral FOXP3 positive T cells were associated with a higher risk of recurrence and poor overall survival of patients with a variety of solid neoplasms. Significant tissue infiltration of Treg were also observed in cases of malignant transformation.
FOXP3 is a member of the forkhead box(FOX) transcription factors, found to be a regulator in the development and function of regulatory T cells (Treg). While FOXP3 has been widely accepted as the best marker for Treg identification, it can also be transiently expressed on non-regulatory CD4+ T-cells upon T-cell antigen receptor activation, and in nonlymphocytic normal or cancer cells. Tregs are defined as immunosuppressive T cells that can mediate local suppression of antitumor immunity and also inhibit functions of dendritic cells, natural killer cells and B cells. Recruitment of Tregs into tumors has been suggested as one of the mechanisms by which malignant cells evade host immunity. treg tumor infiltration, an enlarged pool of Treg in the peripheral blood, and draining lymph nodes have been observed in multi cancer types. Intratumoral FOXP3 positive T cells were associated with a higher risk of recurrence and poor overall survival of patients with a variety of solid neoplasms. Significant tissue infiltration of Treg were also observed in cases of malignant transformation.
