Colon stained with Anti-Cytokeratin 19
Cytokeratin polypeptide 19 (CK19) is a type I intermediate filament protein that is expressed in stratified and simple type epithelia. CK19 is systhesized mainly in embryonic and adult simple epithelia, but has also been found in non-keratinizing stratified epithelia as well. CK19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filament, implying that regulation of its expression is different from other keratin-encoding genes. CK19 antibody is a useful tool for the identification of epithelial tumors. It is helpful in distinguishing hepatocellular carcinoma(CK19) from cholangiocarcinoma (CK19+) or metastatic carcinoma in liver(CK19+)
Cytokeratin polypeptide 19 (CK19) is a type I intermediate filament protein that is expressed in stratified and simple type epithelia. CK19 is systhesized mainly in embryonic and adult simple epithelia, but has also been found in non-keratinizing stratified epithelia as well. CK19 is the smallest known keratin and is remarkable in that, contrary to all other keratins, it does not have a designated partner for the formation of filament, implying that regulation of its expression is different from other keratin-encoding genes. CK19 antibody is a useful tool for the identification of epithelial tumors. It is helpful in distinguishing hepatocellular carcinoma(CK19) from cholangiocarcinoma (CK19+) or metastatic carcinoma in liver(CK19+)
