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Prostate hyperplasia stained with anti-CK5 & CK14 cocktail
Cytokeratin 5 (CK5) is a type II cytokeratin. Antibody to CK5 labels myoepithelial cells of breast and prostate basal cells. CK5 has been useful in different studies as immunohistochemical markers suggesting mesothelioma, and their expression is analyzed for the histological differentiation of adenocarcinomas, especially when facing metastatic tumors of unknown origin. Cytokeratin 14 (CK14) is a 50-kDa keratin expressed in abundance in stratified epithelial, epidermal, basal, mesothelial, and myoepithelial cells in various tissues including breast and prostate. The CK14 antibody is helpful in the identification of breast cancer with a basal phenotype. It has been reported that Cytokeratin 5/14-positive breast cancers are true basal phenotype confined to BRCA1 tumors.
Cytokeratin 5 (CK5) is a type II cytokeratin. Antibody to CK5 labels myoepithelial cells of breast and prostate basal cells. CK5 has been useful in different studies as immunohistochemical markers suggesting mesothelioma, and their expression is analyzed for the histological differentiation of adenocarcinomas, especially when facing metastatic tumors of unknown origin. Cytokeratin 14 (CK14) is a 50-kDa keratin expressed in abundance in stratified epithelial, epidermal, basal, mesothelial, and myoepithelial cells in various tissues including breast and prostate. The CK14 antibody is helpful in the identification of breast cancer with a basal phenotype. It has been reported that Cytokeratin 5/14-positive breast cancers are true basal phenotype confined to BRCA1 tumors.
