Tonsil stained with Anti-CD38
CD38, also called ADP ribosyl cyclase, is an ectoenzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second IVD messengers. In particular, it synthesizes cyclic ADP ribose, a second messenger for glucose induced insulin secretion. CD38 also has cADPR hydrolase activity. It is preferentially expressed at both early and late stages of B and T cell maturation. CD38 is expressed in a variety of non-hematopoietic and hematopoietic cells, activated T cells, and B cells at early and late stages of differentiation, such as plasma cells. In normal lymphnodes and tonsils, the antigen is detected mainly on B cells in germinal centers and plasma cells.
CD38, also called ADP ribosyl cyclase, is an ectoenzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second IVD messengers. In particular, it synthesizes cyclic ADP ribose, a second messenger for glucose induced insulin secretion. CD38 also has cADPR hydrolase activity. It is preferentially expressed at both early and late stages of B and T cell maturation. CD38 is expressed in a variety of non-hematopoietic and hematopoietic cells, activated T cells, and B cells at early and late stages of differentiation, such as plasma cells. In normal lymphnodes and tonsils, the antigen is detected mainly on B cells in germinal centers and plasma cells.
