Hodgkins Lymphoma stained with Anti CD15
CD15 is expressed on Reed-Sternberg cells of Hodgkin's diseases and by various other cell types including myeloid cells and epithelial cells. CD15 recognizes a pentasaccharide sequence occurring in lacto-N-fucopentaose III ceramide (also referred to as Xhapten of Lex) found in higher glycolipids and glycoproteins. A review by Arber et al. has reported that antibodies to CD15 demonstratepositive staining in 87% of Hodgkin's diseases including nodular sclerosing, mixed cellularity, and lymphocyte depletion, whereas the lymphocyte predominant variant exhibits a lower rate of positivity.
CD15 is expressed on Reed-Sternberg cells of Hodgkin's diseases and by various other cell types including myeloid cells and epithelial cells. CD15 recognizes a pentasaccharide sequence occurring in lacto-N-fucopentaose III ceramide (also referred to as Xhapten of Lex) found in higher glycolipids and glycoproteins. A review by Arber et al. has reported that antibodies to CD15 demonstratepositive staining in 87% of Hodgkin's diseases including nodular sclerosing, mixed cellularity, and lymphocyte depletion, whereas the lymphocyte predominant variant exhibits a lower rate of positivity.
