Thoracic undifferentiated Tumor stained with anti-BRG1
BRG-1 is a transcriptional co-activator cooperating with nuclear hormone receptors to potentiate transcriptional activation. BRG1 (SMARCA4) is a documented tumor suppressor and a key subunit of the SWI/SNF chromatin remodeling complex that is silenced in a spectrum of tumor types. Brahma-related gene-1 (BRG-1) protein is encoded by the gene SMARCA-4, which is localized on chromosome 19. BRG-1 is the core catalytic ATPase subunit of the SWItch/sucrose non-fermentable (SWI/SNF) complex. SWI/SNFs are a member of the family of ATP-dependent chromatin-remodeling complexes and the function of SWI/SNFs is to facilitate the transcriptional activation or repression of target genes. BRG-1 is essential for DNA repair, differentiation, and organ development. It was found that the loss of BRG-1 occurs in a portion of tested cancers types, including Breast, Colon, Head/Neck, Ovarian, Liver and Renal Cell Cancer.
BRG-1 is a transcriptional co-activator cooperating with nuclear hormone receptors to potentiate transcriptional activation. BRG1 (SMARCA4) is a documented tumor suppressor and a key subunit of the SWI/SNF chromatin remodeling complex that is silenced in a spectrum of tumor types. Brahma-related gene-1 (BRG-1) protein is encoded by the gene SMARCA-4, which is localized on chromosome 19. BRG-1 is the core catalytic ATPase subunit of the SWItch/sucrose non-fermentable (SWI/SNF) complex. SWI/SNFs are a member of the family of ATP-dependent chromatin-remodeling complexes and the function of SWI/SNFs is to facilitate the transcriptional activation or repression of target genes. BRG-1 is essential for DNA repair, differentiation, and organ development. It was found that the loss of BRG-1 occurs in a portion of tested cancers types, including Breast, Colon, Head/Neck, Ovarian, Liver and Renal Cell Cancer.
