Endometrial carcinoma stained with Anti-SDHB
Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression. SDHB is also known as Succinate Dehydrogenase Complex Iron Sulfur Subunit B, Iron-Sulfur Subunit Of Complex II, SDH1, SDH, Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial, Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip), Succinate Dehydrogenase Complex Subunit B, Iron Sulfur (Ip), Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, EC 1.3.5.1, MC2DN4, PPGL4, SDHIP, CWS2, PGL4, SDH2, IP, Ip.
Succinate dehydrogenase B (SDHB) is an iron-sulfur subunit of mitochondrial complex II, a key component of the citric acid cycle and the electron transport chain, a respiratory complex that catalyzes the oxidation of succinate in the mitochondrial membrane. Many cancers are generally positive for SDHB, including renal cell carcinomas and gastrointestinal stromal tumors. A subset of RCC and GIST tumors that are associated with SDH mutations, Carney-Stratakis Syndrome or Carney Triad exhibit a loss of SDHB expression. SDHB is also known as Succinate Dehydrogenase Complex Iron Sulfur Subunit B, Iron-Sulfur Subunit Of Complex II, SDH1, SDH, Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, Mitochondrial, Succinate Dehydrogenase Complex, Subunit B, Iron Sulfur (Ip), Succinate Dehydrogenase Complex Subunit B, Iron Sulfur (Ip), Succinate Dehydrogenase [Ubiquinone] Iron-Sulfur Subunit, EC 1.3.5.1, MC2DN4, PPGL4, SDHIP, CWS2, PGL4, SDH2, IP, Ip.
