PRAME-EP461

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein. PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes. PRAME can be used to distinguish between malignant melanoma cells and nevus cells, and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA) and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas, and the majority of mucosal melanomas.

• Source
  Rabbit Monoclonal
• Clone
  EP461
• Class
  IVD
• Isotype
  Rabbit, IgG
• Tested Reactivity
  Human, FFPE
• Localization
  Nucleus and/or Membrane
• Positive Control
  Melanoma, Testis

• Catalog
  Pack Size
• MR1318-3ml
  3ml (RTU)
• MR1318-6ml
  6ml (RTU)
• MRC1318-0.1ml
  0.1ml (Conc.)
• MRC1318-0.5ml
  0.5ml (Conc.)
• MRC1318-1ml
  1ml (Conc.)
• MRH1318-3ml
  3ml (RTU)
• MRH1318-6ml
  6ml (RTU)