Dysgeminoma Stained with Anti-Podoplanin
Podoplanin was first identified as a transmembrane glycoprotein in the podocytes of rat kidney. Podoplanin acts as receptor for selectins (which mediate inflammatory cell adhesion) and is involved in cell maturation and migration by filopodia formation (via the downregulation of the activities of small Rho family GTPases). Podoplanin is found in lymphatic endothelium (but not blood vessel endothelium), fibroblasts, osteocytes, follicular dendritic cells, smooth and striated muscle cells, myoepithelial cells, Cajal cells, basal cells in squamous epithelium (tonsil), gastric crypt cells, prostatic basal cells, immature Sertoli cells and foetal gonocytes (but not the corresponding cells of the adult testis),renal glomerular podocytes, mesothelium (particularly when reactive), subsets of lymphocytes, Schwann cells, glial and ependymal cells. Podoplanin is a very useful marker in the differentiation between malignant mesothelioma and adenocarcinoma, and the identification of seminoma/dysgerminoma/IGCN. Podoplanin is also known as PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, and D2-40.
Podoplanin was first identified as a transmembrane glycoprotein in the podocytes of rat kidney. Podoplanin acts as receptor for selectins (which mediate inflammatory cell adhesion) and is involved in cell maturation and migration by filopodia formation (via the downregulation of the activities of small Rho family GTPases). Podoplanin is found in lymphatic endothelium (but not blood vessel endothelium), fibroblasts, osteocytes, follicular dendritic cells, smooth and striated muscle cells, myoepithelial cells, Cajal cells, basal cells in squamous epithelium (tonsil), gastric crypt cells, prostatic basal cells, immature Sertoli cells and foetal gonocytes (but not the corresponding cells of the adult testis),renal glomerular podocytes, mesothelium (particularly when reactive), subsets of lymphocytes, Schwann cells, glial and ependymal cells. Podoplanin is a very useful marker in the differentiation between malignant mesothelioma and adenocarcinoma, and the identification of seminoma/dysgerminoma/IGCN. Podoplanin is also known as PDPN, AGGRUS, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A, and D2-40.
