Clear Cell RCC stained with Anti-PAX2
PAX-2 is a member of the PAX family of transcription factors that together with PAX-8, is involved in the regulation of the organogenesis of the kidney and the Mullerian system. Among the non-neoplastic tissue, PAX-2 was expressed in glomerular parietal epithelial cells, renal collecting duct cells, atrophic renal tubular cells, epithelial cells of ovarian surface, fallopian tube, endocervix, and endometrium. Among the primary neoplasms, PAX-2 was mainly noted in renal cell carcinoma, carcinomas of Mullerian origin, nephrogenic adenomas. Recent investigations have indicated that PAX-2 could serve as a useful immunohistochemical marker that can assist in the diagnosis of epithelial tumors of the kidney, as well as some gynecologic neoplasms.
PAX-2 is a member of the PAX family of transcription factors that together with PAX-8, is involved in the regulation of the organogenesis of the kidney and the Mullerian system. Among the non-neoplastic tissue, PAX-2 was expressed in glomerular parietal epithelial cells, renal collecting duct cells, atrophic renal tubular cells, epithelial cells of ovarian surface, fallopian tube, endocervix, and endometrium. Among the primary neoplasms, PAX-2 was mainly noted in renal cell carcinoma, carcinomas of Mullerian origin, nephrogenic adenomas. Recent investigations have indicated that PAX-2 could serve as a useful immunohistochemical marker that can assist in the diagnosis of epithelial tumors of the kidney, as well as some gynecologic neoplasms.
