p21, also known as cyclin-dependent kinase Inhibitor 1 or CDK-Interacting protein 1. is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2). The p21 protein binds to and inhibits the activity of cyclin- CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. PRINCIPLE OF THE PROCEDURE 21 is expressed in all adult human tissues. In tumors, the expression of p21 has been studied by immunohistochemical methods in a wide range of human tumors. such as gastric carcinoma, non-small cell lung carcinoma, and thyroid carcinoma. The expression of p21 is associated with favorable prognosis in various tumors. p21 is also known as CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A or cyclin dependent kinase inhibitor 1A.
p21, also known as cyclin-dependent kinase Inhibitor 1 or CDK-Interacting protein 1. is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2). The p21 protein binds to and inhibits the activity of cyclin- CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. PRINCIPLE OF THE PROCEDURE 21 is expressed in all adult human tissues. In tumors, the expression of p21 has been studied by immunohistochemical methods in a wide range of human tumors. such as gastric carcinoma, non-small cell lung carcinoma, and thyroid carcinoma. The expression of p21 is associated with favorable prognosis in various tumors. p21 is also known as CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A or cyclin dependent kinase inhibitor 1A.