Ovarian Adeno Ca stained with Anti-MMP7
The matrix metalloprotenaise-7,MMP-7,also known as matrilysin, is a member of the MMP family of Zinc-and calcium dependent endopeptidases that degrade matrix glycoproteins. MMP-7 has proteolytic activity against a broad range of substrates,including collagen,proteoglycans, elastin , laminin , fibronectin and casein. MMP-7 may play an important role in tumor invasion and metastates. It is produced in neoplastic cells and upregulated during neoplastic growth. MMP-7 expression was reported to be produced by malignant tumor cells in esophageal, gatric, colorectal ,head and neck, lung, prostate and hepatocellular carcinoma. Immunohistochemical studies have shown MMP-7 expression association with depth of tumor invasion, advanced tumor stage, and recurrence. Progressive MMP-7 expression was observed in the transition from normal to adenomatous to carcinomatous colonic mucosa, and overexpressed in 85% of colorectal adenocarcinomas. Over expression of MMP-7 is typically associated with poor prognosis
The matrix metalloprotenaise-7,MMP-7,also known as matrilysin, is a member of the MMP family of Zinc-and calcium dependent endopeptidases that degrade matrix glycoproteins. MMP-7 has proteolytic activity against a broad range of substrates,including collagen,proteoglycans, elastin , laminin , fibronectin and casein. MMP-7 may play an important role in tumor invasion and metastates. It is produced in neoplastic cells and upregulated during neoplastic growth. MMP-7 expression was reported to be produced by malignant tumor cells in esophageal, gatric, colorectal ,head and neck, lung, prostate and hepatocellular carcinoma. Immunohistochemical studies have shown MMP-7 expression association with depth of tumor invasion, advanced tumor stage, and recurrence. Progressive MMP-7 expression was observed in the transition from normal to adenomatous to carcinomatous colonic mucosa, and overexpressed in 85% of colorectal adenocarcinomas. Over expression of MMP-7 is typically associated with poor prognosis
