Neuroendo crine tumor stained with Anti-INSM1
INSM-1 (insulinoma-associated protein 1), also known as zinc-finger protein IA-1, is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic tissues undergoing neuroendocrine differentiation. It plays an important role in neuroendocrine development and is required for normal differentiation of pancreatic endocrine cells. Inhibition of INSM-1 results in decreased formation of glucagon and Insulin positive cells. INSM1 is not expressed in normal adult tissues but it can be found highly expressed in neuroendocrine tumors. INSM1 is mainly used in clinical diagnosis of neuroendocrine tumors. INSM-1 is also known as INSM Transcriptional Repressor 1, IA1, IA-1, Insulinoma-Associated Protein 1, Zinc Finger Protein IA-1, Insulinoma-Associated 1, Insulinoma Associated 1.
INSM-1 (insulinoma-associated protein 1), also known as zinc-finger protein IA-1, is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic tissues undergoing neuroendocrine differentiation. It plays an important role in neuroendocrine development and is required for normal differentiation of pancreatic endocrine cells. Inhibition of INSM-1 results in decreased formation of glucagon and Insulin positive cells. INSM1 is not expressed in normal adult tissues but it can be found highly expressed in neuroendocrine tumors. INSM1 is mainly used in clinical diagnosis of neuroendocrine tumors. INSM-1 is also known as INSM Transcriptional Repressor 1, IA1, IA-1, Insulinoma-Associated Protein 1, Zinc Finger Protein IA-1, Insulinoma-Associated 1, Insulinoma Associated 1.
