Neuroendocrine Tumor stained with Anti GRIA-2
Glutamate Receptor2(GRIA2) is a ligand gated ion channel that uses l-glutamate for excitatory synaptic transmission expressed in the central nervous system. A recent gene expression profiling study reported> 100 fold GRIA2 induction in solitary fibrous tumors compared with control tissues. Immunohistochemistry studies demonstrated GRIA-2 positivity in the majority of solitary fibrous tumors(64-86%).Its diagnostic performance yields 64% sensitivity , 92% specificity , with 41% and 97% positive and negative predictive value,respectively for the differential diagnosis of solitary fibrous tumors versus other mesenchymal soft tissue tumors.GRIA-2 may be useful marker to identify STST-6 negative Solitary fibrous tumors.
Glutamate Receptor2(GRIA2) is a ligand gated ion channel that uses l-glutamate for excitatory synaptic transmission expressed in the central nervous system. A recent gene expression profiling study reported> 100 fold GRIA2 induction in solitary fibrous tumors compared with control tissues. Immunohistochemistry studies demonstrated GRIA-2 positivity in the majority of solitary fibrous tumors(64-86%).Its diagnostic performance yields 64% sensitivity , 92% specificity , with 41% and 97% positive and negative predictive value,respectively for the differential diagnosis of solitary fibrous tumors versus other mesenchymal soft tissue tumors.GRIA-2 may be useful marker to identify STST-6 negative Solitary fibrous tumors.
