Neck tumar squamous cell carcinoma Stained with Anti-EGFR
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas. Other names of EGFR are Epidermal Growth Factor Receptor, ERBB1, ERRP, ERBB, Receptor Tyrosine-Protein Kinase ErbB-1, Erb-B2 Receptor Tyrosine Kinase 1, Proto-Oncogene C-ErbB-1, EC 2.7.10.1, HER1, Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog), Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian), Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog, Epidermal Growth Factor Receptor Tyrosine Kinase Domain Cell Proliferation-Inducing Protein 61, Cell Growth Inhibiting Protein 40, EGFR VIII, EC 2.7.10, NISBD2, PIG61, MENA, mENA, NISBD2, PIG61, erbB-1.
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3, -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head, neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas. Other names of EGFR are Epidermal Growth Factor Receptor, ERBB1, ERRP, ERBB, Receptor Tyrosine-Protein Kinase ErbB-1, Erb-B2 Receptor Tyrosine Kinase 1, Proto-Oncogene C-ErbB-1, EC 2.7.10.1, HER1, Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog), Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian), Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog, Epidermal Growth Factor Receptor Tyrosine Kinase Domain Cell Proliferation-Inducing Protein 61, Cell Growth Inhibiting Protein 40, EGFR VIII, EC 2.7.10, NISBD2, PIG61, MENA, mENA, NISBD2, PIG61, erbB-1.
