Tonsil Stained with Anti-CTLA4
.jpg "Hodgkins Lymphoma-Nodular Sclerosis Stained with Anti-CTLA4 (2)")
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigen presenting cells; and thus CTLA-4 competes with CD28 function in T-cell survival, proliferation, and recruitment. CTLA-4 is also known as Cytotoxic T-Lymphocyte Associated Protein 4, CD152, GSE, CD, Insulin-Dependent Diabetes Mellitus 12, Cytotoxic T-Lymphocyte Protein 4, Gluten-Sensitive Enteropathy, Celiac Disease, CELIAC3, Ligand and Transmembrane Spliced Cytotoxic T Lymphocyte, Associated Antigen 4, Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form, Cytotoxic T-Lymphocyte-Associated Serine Esterase-4, CD152 Antigen, ALPS5, GRD4.
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a member of the CD28 superfamily and is a negative regulator of T cell-mediated immune responses. CTLA-4 expression is induced on the surface of T cells after CD28 binding and activation, and is constitutively expressed on T-regulatory cells, acting as an immune checkpoint inhibitor, downregulating T cell activity. CTLA-4 primarily inactivates T-cell activity by competing with the CD28 costimulatory molecule. CD28 and CTLA-4 share the identical ligands of CD80 and CD86 on antigen presenting cells; and thus CTLA-4 competes with CD28 function in T-cell survival, proliferation, and recruitment. CTLA-4 is also known as Cytotoxic T-Lymphocyte Associated Protein 4, CD152, GSE, CD, Insulin-Dependent Diabetes Mellitus 12, Cytotoxic T-Lymphocyte Protein 4, Gluten-Sensitive Enteropathy, Celiac Disease, CELIAC3, Ligand and Transmembrane Spliced Cytotoxic T Lymphocyte, Associated Antigen 4, Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form, Cytotoxic T-Lymphocyte-Associated Serine Esterase-4, CD152 Antigen, ALPS5, GRD4.
