Tonsil stained with Anti-CD74
Cluster of Differentiation 74(CD74) is a type II transmembrane protein. In normal tissues, CD74 is expressed in B-cells, monocytes, macrophages, langerhans cells, dendritic cells, subsets of activated T-cells, and thymic epithelium. Under inflammatory conditions, CD74 expression may be observed in endothelial and certain epithelial cells. CD74 expression has been observed in ~90% of B-cell cancers evaluated, as well as the majority of cell lines derived from these cancers. CD74 is a marker for distinguishing atypical fibroxanthoma from malignant fibrous histiocytoma, and it is also a useful marker for distinguishing leimyosarcoma from leiomyoma.
Cluster of Differentiation 74(CD74) is a type II transmembrane protein. In normal tissues, CD74 is expressed in B-cells, monocytes, macrophages, langerhans cells, dendritic cells, subsets of activated T-cells, and thymic epithelium. Under inflammatory conditions, CD74 expression may be observed in endothelial and certain epithelial cells. CD74 expression has been observed in ~90% of B-cell cancers evaluated, as well as the majority of cell lines derived from these cancers. CD74 is a marker for distinguishing atypical fibroxanthoma from malignant fibrous histiocytoma, and it is also a useful marker for distinguishing leimyosarcoma from leiomyoma.
