Plasmacytoma Stained with Anti-cd38
CD38 is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It is a marker of cell activation. The CD38 protein has been linked to HIV infection, Leukemias, Myelomas, solid tumors, Type II Diabetes Mellitus and bone metabolism, as well as some genetically-determined conditions. It has also been used as a prognostic marker in Leukemia. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages, and may be detected on cells from Multiple Myeloma, ALL (B and T) and some AML. CD38 antibody expression is useful in subtyping of Lymphomas and Leukemias, inhibition of B-lymphopoiesis, detection of plasma cells, protection of B-cells from apoptosis, and as a marker for activated B and T-cell proliferation. CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, ADP-Ribosyl Cyclase 1, CADPR1, ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1, ADPRC 1, 2'-Phospho-ADP-Ribosyl Cyclase andCyclic ADP-Ribose Hydrolase 1.
CD38 is a glycoprotein found on the surface of many immune cells (white blood cells), including CD4+, CD8+, B and natural killer cells. It is a marker of cell activation. The CD38 protein has been linked to HIV infection, Leukemias, Myelomas, solid tumors, Type II Diabetes Mellitus and bone metabolism, as well as some genetically-determined conditions. It has also been used as a prognostic marker in Leukemia. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages, and may be detected on cells from Multiple Myeloma, ALL (B and T) and some AML. CD38 antibody expression is useful in subtyping of Lymphomas and Leukemias, inhibition of B-lymphopoiesis, detection of plasma cells, protection of B-cells from apoptosis, and as a marker for activated B and T-cell proliferation. CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, ADP-Ribosyl Cyclase 1, CADPR1, ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1, ADPRC 1, 2'-Phospho-ADP-Ribosyl Cyclase andCyclic ADP-Ribose Hydrolase 1.
