ATRX-XH2P

ATRX plays a role in chromatin regulation and maintenance of telomeres. It regulates incorporation of histone H3.3 into telomeric chromatin. ATRX is also a major component of various essential cellular pathways such as DNA replication and repair, chromatin higher-order structure regulation, gene transcriptional regulation, etc. ATRX loss was observed in grades II/III astrocytomas, oligoastrocytomas, oligodendrogliomas, and glioblastomas. Assessment of ATRX loss by immunohistochemical staining captures the majority of mutations, indicating that the use of immunohistochemical testing in routine neuropathology diagnostics gives a reasonable sensitivity.

• Source
  Rabbit Monoclonal
• Clone
  XH2P
• Class
  IVD
• Isotype
  Rabbit, IgG
• Tested Reactivity
  Human, FFPE
• Localization
  Nucleus
• Positive Control
  Glioblastoma Multiforme, Astrocytoma

• Catalog
  Pack Size
• MR1310-3ml
  3ml (RTU)
• MR1310-6ml
  6ml (RTU)
• MRC1310-0.1ml
  0.1ml (Conc.)
• MRC1310-0.5ml
  0.5ml (Conc.)
• MRC1310-1ml
  1ml (Conc.)
• MRH1310-3ml
  3ml (RTU)
• MRH1310-6ml
  6ml (RTU)