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Bladder Ca stained with anti-GATA3

GATA3-L50-823

GATA-3(GATA binding protein 3) is a member of the GATA family of transcription factors. This 50 kD anuclear protein regulates the development and subsequent maintenance of a variety of human tissues, including hematopoietic cells, skin, kidney, mammary gland, and the central nervous system. Among several other roles, GATA-3 involved in luminal cell differentiation in the mammary gland and appears to control a set of genes involved in the differentiation and proliferation of breat cancer. The expression of GATA-3 is associated with the expression of estrogen receptor-alpha (ER) in breast cancer. GATA-3 has been shown to be a novel marker for bladder cancer. The study demonstrated that GATA-3 stained 67% of urothelial Carcinomas, but none of prostate or renal carcinomas.

Specifications

  • Source
    Mouse Monoclonal
  • Clone
    L50-823
  • Class
    IVD
  • Isotype
    Mouse IgG1/k
  • Tested Reactivity
    Human, FFPE
  • Localization
    Nucleus
  • Positive Control
    Bladder Ca

Ordering Information

  • Catalog
    Pack Size
  • PM199-3ml
    3 ml(RTU)
  • PM199-6ml
    6 ml(RTU)
  • CM199-0.1ml
    0.1 ml(Conc.)
  • CM199-0.5ml
    0.5 ml(Conc.)
  • HAM199-3ml
    3 ml(RTU)
  • HAM199-6ml
    6 ml(RTU)