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Tonsil stained with anti-Bcl-2

Bcl-2- EP36

The Bcl-2 family of proteins regulates apoptosis by controlling mitochondrial permeability and release of cytochrome c. Bcl-2 is an anti-apoptotic protein that resides in the outer mitochondrial wall and inhibits release of cytochrome c. Over-expression of Bcl-2 has been shown to promote cell survival by suppressing apoptosis. It has been documented that bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore activated in B cell malignancies. Bcl-2 antibody is useful in differentiation of follicular lymphoma from reactive follicular proliferation(Bcl-2 negative). In addition, Bcl-2 expression has been shown to be correlated with disease prognosis in breast cancer, prostate cancer, ovarian cancer,endometrial cancer and colon cancer. 

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP36
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Cytoplasmic
  • Positive Control
    Tonsil, Follicular Lymphoma

Ordering Information

  • Catalog
    Pack Size
  • PR004-3ml
    3 ml(RTU)
  • PR004-6ml
    6 ml(RTU)
  • CR004-0.1ml
    0.1 ml(Conc.)
  • CR004-0.5ml
    0.5 ml(Conc.)
  • HAR004-3ml
    3 ml(RTU)
  • HAR004-6ml
    6 ml(RTU)