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Tonsil stained with anti-Bcl-6

Bcl-6-EP278

Bcl-6 is a kruppel-type zinc finger transcription factor spanning 706 amino acids. Bcl-6 plays a central role in germinal centre (GC) formation, functioning as a regular of B lymphocyte growth and development by protecting GC B cells from undergoing DNA damage induced apoptosis. Logarajah S et al. found that Bcl-6 is involved in mammary epithelial differentiation, which may play a potential role in carcinogenesis. Bcl-6 expression is mainly localized in GC B-cells. Surrounding mantle and marginal zone B cells, as well as plasma cells and Bone marrow B-cell precursors are negative for Bcl-6. Bcl-6 protein is commonly detected in GC neoplasms including follicular lymphomas, diffuse large B-cell lymphoma (DLBCL) and Burkitt's lymphomas. Bcl-6 is not restricted to B-cell lineage, a considerable number of anaplastic large cell lymphoma also had Bcl-6 expression, especially in ALK positive cases.

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP278
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human, FFPE
  • Localization
    Nuclear
  • Positive Control
    Tonsil, Follicular Lymphoma

Ordering Information

  • Catalog
    Pack Size
  • PR166-3ml
    3ml (RTU)
  • PR166-6ml
    6 ml(RTU)