Close
Burkitt's Lymphoma stained with anti-OCT-2

OCT-2-EP284

Octamer transcription factor-2 (OCT-2) possesses a leucine zipper domain and belongs to the POU family of transcription factors. It specifically binds to the octamer motif (5- ATTTCAT-3), activates immunoglobulin gene expression and regulates transcription in a number of tissues. OCT-2 is important for the expression of B cell specific genes, such as CD20 and CRISP-3. OCT-2 is expressed in mature B cells, predominantly germinal center B cells. Low expression of OCT-2 has been found in immature B cells, T cells and myelomonocytic cells. OCT-2 reactivity in epithelial cells and neuronal cells has also been reported. The OCT-2 antibody labels various B cell lymphomas with strong expression in germinal center-derived lymphomas. In a study on Hodgkin's lymphoma (HL), OCT-2 positivity has been observed in 15 out of 15 lymphocyte predominance HLs, but none of the 29 classic HLs. 

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP284
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Nucleus
  • Positive Control
    Burkitt's Lymphoma, Tonsil, Non-Hodgkin Lymphomas

Ordering Information

  • Catalog
    Pack Size
  • PR245-3ml
    3 ml(RTU)
  • PR245-6ml
    6 ml(RTU)
  • CR245-0.1ml
    0.1 ml(Conc)
  • CR245-0.5ml
    0.5 ml(Conc)
  • HAR245-3ml
    3 ml(RTU)
  • HAR245-6ml
    6 ml(RTU)