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PAX8-PAX8/1491 + PAX8/1492

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors.

Specifications

  • Source
    Mouse Monoclonal
  • Clone
    PAX8/1491 + PAX8/1492
  • Class
    IVD
  • Isotype
    Mouse / IgG2a + IgG2b
  • Tested Reactivity
    Human,FFPE
  • Localization
    Nuclear
  • Positive Control
    Renal Cell Ca

Ordering Information

  • Catalog
    Pack Size
  • PM242-3ml
    3 ml(RTU)
  • PM242-6ml
    6 ml(RTU)
  • CM242-0.1ml
    0.1 ml(Conc)
  • CM242-0.5ml
    0.5 ml(Conc.)
  • HAM242-3ml
    3 ml(RTU)
  • HAM242-6ml
    6 ml(RTU)