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Transcription Factor PU.1-EP18

PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development. Antibody against PU.1 stains B lymphocyte in germinal center and mantle B cell, but not plasma cell. Anti-PU.1 labels many types of B cell lymphoma including mantle cell lymphoma, but PU.1 is not expressed in classical Hodgkin lymphoma (cHL). The lack of transcription factor PU.1 protein expression in cHL, a lymphoproliferative disease of predominantly B-cell origin, likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHL.

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP18
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Nuclear
  • Positive Control
    Tonsil, Lymphoma

Ordering Information

  • Catalog
    Pack Size
  • PR238-3ml
    3 ml(RTU)
  • PR238-6ml
    6 ml(RTU)
  • CR238-0.1ml
    0.1 ml(Conc.)
  • CR238-0.5ml
    0.5 ml(Conc.)
  • HAR238-3ml
    3 ml(RTU)
  • HAR238-6ml
    6 ml(RTU)