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Pituitary gland stained with anti-PTH

PTH-PTH/911

Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Specifications

  • Source
    Mouse Monoclonal
  • Clone
    PTH/911
  • Class
    IVD
  • Isotype
    Mouse IgG2b kappa
  • Tested Reactivity
    Human,FFPE
  • Localization
    Cytoplasm and secreted
  • Positive Control
    Pituitary gland,Parathyroid gland carcinoma

Ordering Information

  • Catalog
    Pack Size
  • PM234-3ml
    3 ml(RTU)
  • PM234-6ml
    6 ml(RTU)
  • CM234-0.1ml
    0.1 ml(Conc.)
  • CM234-0.5ml
    0.5 ml(Conc.)
  • HAM234-3ml
    3 ml(RTU)
  • HAM234-6ml
    6 ml(RTU)