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Breast Ca stained with anti-CDK4

CDK4-EP180

Cyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thr protein kinase family. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a). Overexpression of CDK4 has been observed in many tumor types, including oral squamous cell carcinoma and cancers of the pancreatic (endocrine tumors), lung, breast and colon. The expression of CDK4 is associated with tumor progression. Binh et al. reported a high expression of CDK4 (92%) in atypical lipomatous tumor/well-differentiated liposarcomas (ALT-WDLPS) and dedifferentiated liposarcomas (DDLPS) by immunostaining. CDK4 is useful in differentiating ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas. 

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP180
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Nuclear, Cytoplasmic
  • Positive Control
    Breast Ca, Colon

Ordering Information

  • Catalog
    Pack Size
  • PR232-3ml
    3 ml(RTU)
  • PR232-6ml
    6 ml(RTU)
  • CR232-0.1ml
    0.1 ml(Conc.)
  • CR232-0.5ml
    0.5 ml(Conc.)
  • HAR232-3ml
    3 ml(RTU)
  • HAR232-6ml
    6 ml(RTU)