Close
Astrocytoma stained with anti-ATRX

ATRX-D5

ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX predominately associates with the nuclear matrix, while during mitosis, ATRX localizes with condensed chromatin. At the onset of M phase, phospho- rylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes, where it then specifically complexes with hete- rochromatin protein 1 α to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with α thalassaemia or ATRX syndrome.

Specifications

  • Source
    Mouse Monoclonal
  • Clone
    D5
  • Class
    IVD
  • Isotype
    Mouse IgG2a
  • Tested Reactivity
    Human,FFPE
  • Localization
    Nuclear
  • Positive Control
    Astrocytoma, Glioma

Ordering Information

  • Catalog
    Pack Size
  • PM229-3ml
    3 ml(RTU)
  • PM229-6ml
    6 ml(RTU)
  • CM229-0.1ml
    0.1 ml(Conc.)
  • CM229-0.5ml
    0.5 ml(Conc.)
  • HAM229-3ml
    3 ml(RTU)
  • HAM229-6ml
    6 ml(RTU)