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Seminoma stained with anti-SALL4

SALL4-EP299

The Sal-like protein 4, SALL4 is a zinc finger transcription factor located on chromosome 20q13.13-13.2. It is essential during development by maintaining embryonic stem cell pluripotency and self-renewal. Mutations in SALL4 lead to acro-renal-ocular and Okihiro syndromes, a disorder of the eyes and abnormalities of bones in the arms and hands. Recently, SALL4 has been identified as a novel sensitive diagnostic marker for germ cell tumors. Strong SALL4 staining was observed in all seminoma/dysgerminoma/germinomas, embryonal carcinomas, and yolk sac tumors, yielding 100% sensitivity for these malignancies. Compared with α-fetoprotein and glypican-3, SALL4 demonstrated superior sensitivity in detecting yolk sac tumors. Focal SALL4 staining was also observed in choriocarcinomas (66-71%) and teratomas (50-64%). In non-germ cell tumors, SALL4 is expressed in all cases of acute myeloid leukemia, and majority of Precursor B-cell acute lymphoblastic lymphomas (79%). In a large immunohistochemical study of >3200 cases, SALL4 was also detected in ~20% of cases of ovarian, urothelial and gastric adenocarcinomas, and <5% in mammary, colorectal, prostatic and squamous cell carcinomas

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP299
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Nuclear
  • Positive Control
    Seminoma,Yolksac Tumor, Germcell tumor

Ordering Information

  • Catalog
    Pack Size
  • PR227-3ml
    3 ml(RTU)
  • PR227-6ml
    6 ml(RTU)
  • CR227-0.1ml
    0.1 ml(Conc)
  • CR227-0.5ml
    0.5 ml(Conc.)
  • HAR227-3ml
    3 ml(RTU)
  • HAR227-6ml
    6 ml(RTU)