Recognizes protein about 50kDa,which is identified as gamma-enalose. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoform exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful markers to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. This antibody may be employed in combination with other markers such as Synaptophysin, Chromogranin A and Neurofilament.