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Tonsil stained with anti-CD8

CD8-EP334

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that functions as a co-receptor with the T-cell receptor (TCR). The CD8 molecule consist of a heterodimer of α and β chains covalently linked by a disulfide bond, and are predominantly expressed on the surface of cytotoxic T cells. CD8 expression can also be detected on natural killer cells, cortical thymocytes, and dendritic cells. Cytotoxic CD8+ T lymphocytes are crucial components of the adaptive immune system that execute immunosurveillance to eliminate nascent tumor cells. Upon simultaneous binding to the major histocompatibility complex (MHC) class I molecule with TCR, cytotoxic T-cell sensitivity is increased 100-fold. CD8 is commonly expressed in T-cell large granular lymphocyte leukemia, and is also co-expressed with CD4 in some T-lymphoblastic lymphoma. Recently, detection of tumor infiltrating CD8+ lymphocytes have been correlated with favorable prognosis and improved survival in patients with colorectal, ovarian, esophageal, renal, lung and pancreatic tumors. A high CD8+/CD4+ T-cell ratio is also associated with improved survival in colon and ovarian cancer patients. 

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP334
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Membrane
  • Positive Control
    Tonsil

Ordering Information

  • Catalog
    Pack Size
  • PR223-3ml
    3 ml(RTU)
  • PR223-6ml
    6 ml(RTU)
  • CR223-0.1ml
    0.1 ml(Conc.)
  • CR223-0.5ml
    0.5 ml(Conc.)
  • HAR223-3ml
    3 ml(RTU)
  • HAR223-6ml
    6 ml(RTU)