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Esophageal Ca stained with anti-IMP3

IMP3-EP286

IMP-3, known as Insulin-like growth factor 2 (IGF-II) mRNA-binding protein 3, is an oncofetal protein that stabilizes IGF-II mRNA for trafficking and plays an important role in cell growth and migration. This 65-70 kDa protein is expressed normally in developing tissues during early embryogenesis in a variety of fetal tissues including the liver, lung kidney, thymus, and placenta, but at low or undetectable levels in normal adult tissues. Recent studies have demonstrated IMP-3 expression in various malignant tumors of the lung, gastrointestinal tract, liver, endometrium, and bladder, while undetectable in adjacent benign tissues. IMP-3 may have a critical role in tumor proliferation, invasion and metastasis, and has been suggested to be an independent marker for poor prognosis in patients with clear cell carcinomas.

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP286
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Cytoplasm
  • Positive Control
    Esophageal Ca, Fetal Liver

Ordering Information

  • Catalog
    Pack Size
  • PR221-3ml
    3 ml(RTU)
  • PR221-6ml
    6 ml(RTU)
  • CR221-0.1ml
    0.1 ml(Conc.)
  • CR221-0.5ml
    0.5 ml(Conc.)
  • HAR221-3ml
    3 ml(RTU)
  • HAR221-6ml
    6 ml(RTU)