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Histiocytoma stained with anti-TNF-alpha

TNF-alpha

This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Specifications

  • Source
    Mouse Monoclonal
  • Clone
    TNF1172
  • Class
    IVD
  • Isotype
    Mouse IgM/kappa
  • Tested Reactivity
    Human,FFPE
  • Localization
    Cytoplasm and extracellular (Secreted)
  • Positive Control
    Histiocytoma

Ordering Information

  • Catalog
    Pack Size
  • PM214-3ml
    3 ml(RTU)
  • PM214-6ml
    6 ml(RTU)
  • CM214-0.1ml
    0.1 ml(Conc.)
  • CM214-0.5ml
    0.5 ml(Conc.)
  • HAM214-3ml
    3 ml(RTU)
  • HAM214-6ml
    6 ml(RTU)