Close
Colon Ca stained with anti-c-Myc

c-Myc-EP121

The c-Myc gene is located at chromosome 8q24. It is required for progression through the cell cycle and promotes cellular proliferation. The t(8;14)(q24;q32) translocation and the c-Myc/immunoglobulin heavy-chain (IGH) fusion gene are not only in Burkitt lymphoma, but are also seen in diffuse large B-cell lymphoma, blastic mantle cell lymphoma and transformed follicular lymphoma. In another study on predicting c-Myctranslocation in 17 cases of Burkitt lymphomas (BLs) and 19 cases of diffuse large B-cell lymphomas (DLBCLs), Ruzinova et al. reported that the sensitivity and specificity of this c-Myc antibody on identifying tumor harboring a c-Myc rearrangement reached 96% and 90% respectively. This novel c-Myc antibody is a useful tool for identifying aggressive B-cell lymphomas likely to harbor a c-Myc rearrangement, and thus warrant genetic testing. 

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP121
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human, FFPE
  • Localization
    Nucleus, Cytoplasmic
  • Positive Control
    Colon Ca, Burkitt lymphoma

Ordering Information

  • Catalog
    Pack Size
  • PR034-3ml
    3 ml(RTU)
  • PR034-6ml
    6 ml(RTU)
  • CR034-0.1ml
    0.1 ml(Conc.)
  • CR034-0.5ml
    0.5 ml(Conc.)
  • HAR034-3ml
    3 ml(RTU)
  • HAR034-6ml
    6 ml(RTU)