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p16-G175-405

p16ink4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of variety of malignancies. Recent analysis of the p16ink4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 abnormalities is higher in tumor-derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types leukemia.

Specifications

  • Source
    Mouse Monoclonal
  • Clone
    G175-405
  • Class
    IVD
  • Isotype
    Mouse IgG2b
  • Tested Reactivity
    Human, FFPE
  • Localization
    Cytoplasmic and Nucleus
  • Positive Control
    Cervical Ca

Ordering Information

  • Catalog
    Pack Size
  • PM143-3ml
    3 ml(RTU)
  • PM143-6ml
    6 ml(RTU)
  • CM143-0.1ml
    0.1 ml(Conc.)
  • CM143-0.5ml
    0.5 ml(Conc.)
  • HAM143-3ml
    3 ml(RTU)
  • HAM143-6ml
    6 ml(RTU)