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Appendix stained with anti-MUM 1

MUM1-EP190

MUM1 (multiple myeloma oncogene-1, also called IRF4), a member of the IRF family transcriptional factors, is induced by antigen receptor mediated stimuli and plays a crucial role in cell proliferation, differentiation and survival. In the hematolymphoid system, MUM1 is primarily expressed in B- cells and actived T-lymphoid cells. In B-cells it is expressed on a small subset of germinal center (GC) cells committed to plasmacytic or memory cell differentiation in the “light zone” and in plasma cells. MUM1 has been identified as a marker of non-germinal center- derived DLBCL, a subtype also associated with more aggressive clinical behavior and poor prognosis, but absent in mantle cell lymphoma (pre-GC B-cells) and in follicular lymphoma (GC B-cells). MUM1 may be a potential histo-genetic marker for B-cell lymphomas. Additionally, MUM1 is a useful marker for Reed- Sternberg (HRS) cells in Hodgkin’s lymphoma.

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP190
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human,FFPE
  • Localization
    Nucleus/Cytoplasmic
  • Positive Control
    Appendix, Tonsil,Plasmacytoma

Ordering Information

  • Catalog
    Pack Size
  • PR112-3ml
    3 ml(RTU)
  • PR112-6ml
    6 ml(RTU)
  • CR112-0.1ml
    0.1 ml(Conc.)
  • CR112-0.5ml
    0.5 ml(Conc.)
  • HAR112-3ml
    3 ml(RTU)
  • HAR112-6ml
    6 ml(RTU)