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Tonsil stained with anti-Kappa Light Chain

Kappa Light Chain-EP171

Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two types of light chains designated as kappa and lambda. The gene rearrangement process that generates the immunoglobulin molecule results in either a productive kappa or lambda gene. The mechanics of the rearrangement process normally produce approximately twice as many kappa-bearing cells as lambda. However this ratio is lost during malignant transformation. The kappa light chain antibody labels kappa light chain expressing B-lymphocytes and plasma cells. Other cells may also express kappa light chain due to nonspecific uptake of immunoglobulin. Individual B cells express either kappa or lambda light chains. Monoclonality is generally assumed to be evidence of a malignant proliferation. The pairing of an anti-lambda with a kappa light chain antibody is useful for identifying monoclonality of lymphoid malignancies.

Specifications

  • Source
    Rabbit Monoclonal
  • Clone
    EP171
  • Class
    IVD
  • Isotype
    Rabbit IgG
  • Tested Reactivity
    Human, FFPE
  • Localization
    Membranous, Cytoplasmic
  • Positive Control
    Tonsil, B Cell Lymphoma

Ordering Information

  • Catalog
    Pack Size
  • PR049-3ml
    3 ml(RTU)
  • PR049-6ml
    6 ml(RTU)
  • CR049-0.1ml
    0.1 ml(Conc.)
  • CR049-0.5ml
    0.5 ml(Conc.)
  • HAR049-3ml
    3 ml(RTU)
  • HAR049-6ml
    6 ml(RTU)