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UNIspread Positively Charged Slides-Hydrophilic

Myosin Heavy Chain-EP166

Myosin heavy chain 11(MYH11) is a smooth muscle myosin belonging to the myosin heavy chain family. It is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. Myosin heavy chain functions as a major contractile protein converting chemical energy into mechanical energy through the hydrolysis of ATP. An aberration in this...

Laminin-Polyclonal

This antibody labels laminin,which is present in the basement membrane.The antibody may be useful in the characterization of basement membrane preservation, e.g. in breast cancer and adenocarcinomas of the lung. Laminins have been found to promote cell adhesion,migration,protease activity,proliferation,tumour growth, angiogenesis and metastasis. 

MCM5-EP84

Minichromosome maintenance protein 5 (MCM5), also known as DNA replication licensing factor MCM5, is a member of the MCM family that regulates mammalian DNA replication. This family is composed of six related subunits, called the hexameric MCM2-7 complex, that are conserved in all eukaryotes. It functions as a replicative helicase, the molecular motor that both unwinds duplex DNA and powers fork...

CA 19.9-121SLE

CA19-9, a carbohydrate epitope expressed on a high MW (>400kDa) mucin glycoprotein, is a sialyl Lewisa structure which is synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewis a and/or Lewis b blood group antigens. In normal tissues, sialyl Lewis a antigen is present in ductal epithelium of the breast, kidney, salivary gland, and sweat glands....

OCT-2-EP115

Octamer transcription factor-2 (OCT-2) possess a leucine zipper domain and belongs to the POU family of transcription factors. It specifically binds to the octamer motif (5- ATTTCAT-3), activates immunoglobulin gene expression and regulates transcription in a number of tissues. OCT-2 is important for the expression of B cell specific genes, such as CD20 and CRISP-3. OCT-2 is expressed in mature B...

PD1-PDCD1/922

PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so...

Ki-67-MIB-1

The Ki-67 protein is a nuclear protein doublet, 345-395 kDa, playing a pivotal role in maintaining cell proliferation. In diagnostic histopathology and cell biology, the antibody has proven valuable for the demonstration of the Ki-67 antigen in normal and neoplastic cells, for example in soft-tissue sarcoma, prostatic adenocarcinoma, and breast carcinoma. The Ki-67 has been confirmed as a very...

Galectin-3-9C4

Galectin-3 is a 31 kD beta-galactosidase binding lectin. It has been associated with binding to the basement membrane glycoprotein laminin. Anti-Galectin-3 has been demonstrated to be valuable in differentiating between benign and malignant thyroid neoplasms in both histologic sections and fine needle aspiration biopsy material. Anti-Galectin-3 antibody has also been useful in identifying...

IgG4-EP138

Human IgG4, one of four subclasses of IgG, contains a gamma 4 heavy chain and a hinge region that is shorter than that of IgG1. No allotypes have been detected on the heavy chains of IgG4. Its two primary effector functions are activating complements and binding to the FcgR of effector cells to initiate phagocytosis. Human IgG4 accounts for less than 6% of the total IgG serum level. Recent...

Uroplakin III-EP321

Uroplakin III (UP III) is one of the four transmembrane proteins (UPIa, UPIb, UPII, and UPIII) that are specifically expressed in terminally differentiated urothelial cells.Studies have shown that UPIII is highly specific for identification of primary and metastatic urothelial carcinomas. However, the sensitivity of UPIII in detection of urothelial carcinoma is moderate. Combined use of a panel...

TNF-alpha

This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed...

AFP-Polyclonal

AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasm, especially yolk sac tumors.

C4D-EP272

C4d is the degradation product of the activated complement factor C4, Following activation and degradation of the C4 molecule, thioester groups are exposed which allow transient, covalent binding of the degradation product C4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. C4d is also found in intracytoplasmic...

LH Alpha-LHa/756

This MAb reacts with a protein of ~13kDa, identified as alpha sub-unit of Luteinizing Hormone (LH). Its structure is similar to the other glycoproteins, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). The protein dimer contains 2 polypeptide units, labeled alpha and beta subunits that are connected by two bridges. The alpha subunits...

TSH-EP254

TSH is a member of the glycoprotein hormone family, constituting a subset of the cystine-knot growth factor superfamily. TSH is produced by the pituitary thyrotrophs and released into circulation in a pulsatile manner. It stimulates thyroid functions using a specific membrane TSH receptor (TSHR) that belongs to the superfamily of G protein-coupled receptors (GPCRs). TSH beta is the beta subunit...

EGFR-EP11

Epidermal growth factor receptor (EGFR) is a 170 kDa transmembrane glycoprotein receptor tyrosine kinase that, when activated by epidermal growth factor (EGF), affects cell growth and differentiation in normal and cancer cells. Binding of EGF or TGF alpha to EGFR activates tyrosine kinase activity of the receptor. The carboxy-terminal tyrosine residues on EGFR, Tyr 1068, Tyr 1148, and Tyr 1173,...

TFE3-EP285

TFE3, known as Transcription Factor E3, is a member of the helix- loop-helix family of transcription factors. TFE3 interacts with several transcriptional regulators to affect cell growth, proliferation and osteoclast and macrophage differentiation. In the immune system, TFE3 plays important roles in modulating immunoglobulin heavy- chain expression and regulating B cell activation. Additionally,...

IMP3-EP286

IMP-3, known as Insulin-like growth factor 2 (IGF-II) mRNA-binding protein 3, is an oncofetal protein that stabilizes IGF-II mRNA for trafficking and plays an important role in cell growth and migration. This 65-70 kDa protein is expressed normally in developing tissues during early embryogenesis in a variety of fetal tissues including the liver, lung kidney, thymus, and placenta, but at low or...

Clusterin-EP181

Clusterin (apolipoprotein J) is a 75 - 80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. It is a stress-induced cytoprotective chaperone protein regulated by HSF1 and functions similarly to a small heat- shock protein. Clusterin is distributed widely in human tissues and fluids, including normal epithelial cells, plasma, cerebrospinal...

CD8-EP334

CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that functions as a co-receptor with the T-cell receptor (TCR). The CD8 molecule consist of a heterodimer of α and β chains covalently linked by a disulfide bond, and are predominantly expressed on the surface of cytotoxic T cells. CD8 expression can also be detected on natural killer cells, cortical thymocytes, and dendritic...

ALK-EP302

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of the insulin receptor superfamily. ALK is typically expressed at low levels in regions of the developing central and peripheral nervous system. ALK may be activated in cancer through multiple mechanisms. The most common mechanism is through formation of a fusion protein from chromosomal translocations, as in the case of anaplastic...

NSE gamma-ENO2/1462

Recognizes protein about 50kDa,which is identified as gamma-enalose. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoform exist as both homodimers and heterodimers, and they play a role in converting...

SALL4-EP299

The Sal-like protein 4, SALL4 is a zinc finger transcription factor located on chromosome 20q13.13-13.2. It is essential during development by maintaining embryonic stem cell pluripotency and self-renewal. Mutations in SALL4 lead to acro-renal-ocular and Okihiro syndromes, a disorder of the eyes and abnormalities of bones in the arms and hands. Recently, SALL4 has been identified as a novel...

CD163-EP324

CD163 is an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, thereby protecting tissues from free hemoglobin- mediated oxidative damage. Expression of CD163 is restricted to cells of the monocyte/macrophage lineage. This antibody labels monocytes and macrophages in the spleen and peripheral blood. The CD163 antibody might...

ATRX-D5

ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucelosome structure in an ATP-dependent manner, and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle where it is differentially distributed within the nucleus. During interphase, ATRX...

Arginase 1-ARG1/1125+ARG1/1126

Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle,...

Podoplanin-D2-40

Mouse anti human podoplanin antibody, clone D2-40 was raised against M2A antigen and detects podoplanin. Podoplanin (PDPN) is an O-glycosylated transmembrane glycoprotein that is selectively expressed by, and is a marker of, lymphatic endothelial cells. In normal tissue the 38 kDa protein is also present in human lung, placenta, heart, skeletal muscle and kidney podocytes. It is not found in the...

CDK4-EP180

Cyclin-dependent kinase 4 (CDK4) is a member of the Ser/Thr protein kinase family. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a). Overexpression of CDK4 has been observed in many...

MUC5AC-CLH2

Mucin 5AC glycoprotein (MUC5AC) is a HMW glycoprotein belonging to the superfamily of mucins. Mucins are produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC5AC is a mucus-forming, secreted mucin that is found in normal gastric and tracheo-bronchial mucosa, but absent from normal colon. MUC5AC expression is present in primary ovarian...

PTH-PTH/911

Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted...

CD35-EP197

CD35, also named as erythrocyte complement receptor 1 (CR1), is a member of the complement activation (RCA) family and is located in the ‘cluster RCA’ region of chromosome 1. CD35 mediates cellular binding to particles and immune complexes that have activated complement. CD35 is present on erythrocytes, various leucocytes and renal glomerular podocytes. In addition, plasma contains a soluble...

ALDH1A1-EP168

ALDH1A1 belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular...

HISTONE H3 PHOSPHO(pT3)-EP233

Histone H3 is a core histone protein, which complexes with the other histones to form the major constituents of chromatin in eukaryotic cells. In mammalian cells, phosphorylation of Threonine 3 residue in histone H3 reaches a maximum for condensation during mitosis. Phosphorylation of histone H3 (pHH3) occurs only during late G2 phase and mitosis. pHH3 is a marker for mitoses in various types of...

Transcription Factor PU.1-EP18

PU.1 is a member of the Ets family of transcription factors and is required for the development of multiple hematopoietic lineages. It plays a pivotal role in normal myeloid differentiation, and regulates the expression of immunoglobulin and other genes that are important for B-cell development. Antibody against PU.1 stains B lymphocyte in germinal center and mantle B cell, but not plasma cell....

SATB2-EP281

DNA-binding protein SATB2, also known as Special AT-rich sequence-binding protein 2, is a nuclear matrix-associated transcription factor. SATB2 acts as a docking site for chromatin remodeling enzymes and recruits co-activators and co-repressors to control nuclear gene expression. SATB2 also regulates skeletal development, osteoblast differentiation, and modulates immunoglobulin expression. In...

DOG1-EP332

DOG1, “discovered on GIST 1” encodes for a protein of unknown function that is highly sensitive and specific for gastrointestinal stromal tumors (GIST). GISTs occur in bowel walls and proposed to originate from the interstitial cells of Cajal. The majority of GISTs harbor activating mutations in KIT but approximate 5-15% of GIST are negative for c-Kit by immunohistochemistry, mainly...

PAX8-PAX8/1491 + PAX8/1492

Recognizes a protein of 62kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the...

FLI-1-G146-22

The FLI-1 gene and FLI-1 protein are best known for their critical role in the pathogenesis of ES/PNET. More than 85% of ES/PNET are characterized by the translocation t(11;22)(q24;q12) that results in the fusion of the ews gene on chromosome 22 to the FLI-1 gene on chromosome 11. FLI-1 is a member of the ETS (erythroblastosis virus-associated transforming sequences) family of DNA-binding...

OCT-2-EP284

Octamer transcription factor-2 (OCT-2) possesses a leucine zipper domain and belongs to the POU family of transcription factors. It specifically binds to the octamer motif (5- ATTTCAT-3), activates immunoglobulin gene expression and regulates transcription in a number of tissues. OCT-2 is important for the expression of B cell specific genes, such as CD20 and CRISP-3. OCT-2 is expressed in mature...

Fascin-EP116

Fascin, an actin-binding protein, induces parallel actin bundles in cell protrusions and cell motility after the formation of lamellipodia or filopodia. The Fascin antibody labels dendritic cells in normal and tumor tissues. It is a sensitive marker for Reed-Sternberg cells in Hodgkin’s lymphoma (HL). Thus, Fascin is useful for the identification of Hodgkin’s lymphoma as well as dendritic...

FOXA1-EP277

FOXA1, also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. FOXA1 has been identified as a hepatocyte enriched factor required for the expression of transthyretin and α1- antitrypsin. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with...

FOXP1-EP137

The FOXP1 protein belongs to a functionally diverse family of winged-helix or forkhead transcription factors that have diverse roles in cellular proliferation, differentiation, and neoplastic transformation. The FOXP1 gene has been mapped to chromosome 3p14.1, a region that commonly shows loss of heterozygosity in a wide range of tumors and is reported to contain a tumor suppressor gene(s). The...

CD41-EP178

CD41, also named GP IIb, is a protein that in human is encoded by the ITGA2B gene. This protein can be associated with GPIIIa to form a heterodimer complex (GPIIb-IIIa) in the presence of Ca2+. This complex can bind one of four different adhesive proteins (i.e,fibrinogen,fibronectin,,von Willebrand factor [Vwf], or vitronectin). CD41 expression has been found on platelets, megakaryocytes, and,...

H.Pylori-EP279

Helicobacter Pylori (H. Pylori) is an endemic helix-shaped Gram- negative bacterium that infected over half of the world’s population, reaching over 80% prevalence in developing countries. The bacterium attaches tightly to the gastric epithelia upon ingestion via unique bacterial-surface components and releases urease, permitting its survival in the acidic lumen. H. Pylori strains are highly...

NeuN(Neuronal nuclei)-A60

NeuN antibody specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal...

Galectin-3-B2C10

Galectin-3 is a 31 kD beta-galactosidase binding lectin. It has been associated with binding to the basement membrane glycoprotein laminin. Anti-Galectin-3 has been demonstrated to be valuable in differentiating between benign and malignant thyroid neoplasms in both histologic sections and fine needle aspiration biopsy material. Anti-Galectin-3 antibody has also been useful in identifying...

p40-ZR8

p63 consists of two major isoforms-TAp63 and ΔNp63. These isoforms differ in the structure of the N terminal domains. The TAp63 isoform (identified by anti-p63 antibody) contains a transactivation competent ‘TA’ domain with homology to p53, which regulates the expression of the growth-inhibitory genes. In contrast, ΔNp63 isoform (identified by anti-p40 antibody) contains an alternative...

Myosin Light Chain-EP99

Myosin is a hexamer of 2 identical heavy chains and 2 pairs of light chains. The two pairs of light chains of muscle myosins are called essential light chains (ELC) and regulatory light chains (RLC). The light chains stabilize the long alpha helical neck of the myosin head. Myosin light chain-2 (MYL2), also known as the regulatory light chain of myosin, is an important protein involved in the...

Deparaffinization and Clearing Station

PathnSitu provides the high quality solvent and stain resistant jars for deparaffinization and clearing of slides in histology and immunohistochemistry labs. The jars are costumed made for high throughput and slide rack holds upto 20 slides. The slide jar and the rack are xylene and alcohol resistant and underwent lots of crash testing in our R &D lab.The jar set is enclosed in metal frame...

CD7-EP132

CD7 is a single-pass type 1 transmembrane protein that is a member of the immunoglobulin superfamily. It plays an essential role in T-cell interactions and also in T-cell/B-cell interactions during early lymphoid development. CD7 is expressed on thymocytes, T- and natural killer cells, and progenitors of lymphoid and myeloid cells. It is also expressed on T-cell Acute Lymphoblastic...

AFP-EP209

Alpha-fetoprotein(AFP) is the most abundant plasma protein found in the human fetus. It is thought to be the fetal form of serum albumin.  AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric, and trimeric forms. Alpha-fetoprotein is synthesized by the cells of the embryonic yolk sac, fetal liver and fetal intestinal tract. AFP levels decrease soon after...

MERS2

Multi Epitope Retrieval System-2 is uniquely designed by PathnSitu Biotechnologies, to perform optimal antigen retrieval triggered by heat and pressure. The customized one touch retrieval programs are validated for Immunohistochemistry application and allows user to select the interest of cellular localization protocols. The system easily can adapt to the high workflow with right efficiency,...

PolyExcel HRP/DAB Detection System-Two Step

PathnSitu uniquely developed PolyExcel micro-polymer detection system, which is compatible with Mouse and Rabbit primary antibodies. The smaller size of polymer in micro-polymer technology adheres to bound protein molecules strongly in shorter incubation time results in enhanced staining expecially for nuclear markers. PathnSitu highly sensitive and specific PolyExcel two step detection system is...